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Meadowdale Labrador Puppies

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Health

 

 

BVA/KC scoring scheme for elbow dysplasia (ED) was launched in 1998. Dysplasia means abnormal development, and the degree of elbow dysplasia present is indicated by a grade assigned to each elbow on a scale of 0 to 3 (0 being the best and 3 being the most severe). Only the highest grade of the two elbows is taken as the elbow grade for that dog. The minimum age for elbow grading is one year, and each dog is only ever graded once under the scheme. Advice to breeders is wherever possible to use only those dogs with grades of 0 or 1 for breeding.  

 

 

 

in Labrador Retrievers is an hereditary myopathy characterised by skeletal muscle problems such as muscle weakness and exercise intolerance. It is also known as hereditary myopathy of the Labrador Retriever (HMLR).

 

The mutation, or change to the structure of the gene, probably occurred spontaneously in a single dog but once in the population has been inherited from generation to generation like any other gene. The disorder shows an autosomal recessive mode of inheritance: two copies of the defective gene (one inherited from each parent) have to be present for a dog to be affected by the disease. Individuals with one copy of the defective gene and one copy of the normal gene - called carriers - show no symptoms but can pass the defective gene onto their offspring. When two apparently healthy carriers are crossed, 25% (on average) of the offspring will be affected by the disease, 25% will be clear and the remaining 50% will themselves be carriers

 

 

The genetic disorder, prcd-PRA , causes cells in the retina at the back of the eye to degenerate and die, even though the cells seem to  develop normally early in life. The “rod” cells operate in low light levels and are the first to lose normal function. Night blindness results. Then the “cone” cells gradually lose their normal function in full light situations. Most affected dogs will eventually be blind. Typically, the clinical disease is recognized first in early adolescence or early adulthood. Since age at onset of disease varies among breeds, you should read specific information for your dog. Diagnosis of retinal disease can be difficult. Conditions that seem to be prcd-PRA might instead be another disease and might not be inherited. OptiGen’s genetic test assists in making the diagnosis. It’s important to remember that not all retinal disease is PRA and not all PRA is the prcd form of PRA. Annual eye exams by a veterinary ophthalmologist will build a history of eye health that will help to diagnose disease.

 

Unfortunately, at this time there is no treatment or cure for PRA. If your dog is affected, you may find it helpful to read about other owners’ experiences living with blind dogs. (suggested links:www.eyevet.org and www.blinddogs.com)

 

Inheritance

Prcd-PRA is inherited as a recessive trait. This means a disease gene must be inherited from each parent in order to cause disease in an offspring. Parents were either “carrier” or affected. A carrier has one disease gene and one normal gene, and is termed “heterozygous” for the disease. A normal dog has no disease gene and is termed “homozygous normal” – both copies of the gene are the same. And a dog with two disease genes is termed “homozygous affected” – both copies of the gene are abnormal.

 

It’s been proven that all breeds being tested for prcd-PRA have the same disease caused by the same mutated gene. This is so, even though the disease might develop at different ages or with differing severity from one breed to another.

 

Although prcd-PRA is inherited, it can be avoided in future generations by testing dogs before breeding. Identification of dogs that do not carry disease genes is the key. These "clear" dogs can be bred to any mate

 

 

Hip Dysplasia is a term which includes a number of specific developmental and other abnormalities involving the hip joint.

 

All radiographs submitted to the BVA/KC Hip Dysplasia Scheme are assessed by means of scoring. The hip score is the sum of the points awarded for each of nine radiographic features of both hip joints. The lower the score the less the degree of hip dysplasia present. The minimum (best) score for each hip is zero and the maximum (worst) is 53, giving a range for the total of 0 to 106.  The average score of the breed, or the 'breed mean score', is calculated from all the scores recorded for a given breed and is shown alongside its range thereby giving a representation of the overall hip status of the breed. All breeders wishing to try to control HD should breed only from animals with hip scores well below the breed mean score.  BMS for Labradors at present is .....................

 

The  purpose of the Hip scheme is to reduce the incidence of the disease in dogs used for breeding.  The minimum age of the dog at the time of radiography is 12 months; there is no upper age limit. Dogs may not be scored under the scheme more than once.

Centronuclear Myopathy (CNM)

PRA Disease

BVA/KC Hip Dysplasia Scheme

BVA/KC Elbow Dysplasia Scheme

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EIC - Exercise Induced Collapse

Exercise Induced Collapse is an inherited condition that affects Labrador Retriever and related breeds. Affected dogs can endure mild to moderate exercise but after 5 to 20 minutes of heavy exercise with extreme excitement, the dog shows weakness and then collapse. Severely affected dogs may collapse whenever they are exercised to this extend – other dogs only exhibit collapse episodes sporadically.

Signs of EIC are not typically seen until the dog begin intense training. First symptoms are usually noted between 5 months and 3 years of age. However, it is confirmed that some affected dogs did not have collapse episodes until as late as age 10.

Hip Score

Elbow Score

DNA PRA

DNA CNM

DNA SD2

DNA EIC

Eye Test

Sofia                                                   Cluanie

4-2=6                                             3-3=6

0                                                     0

Clear                                             Clear

Clear                                             Clear

Clear                                             Clear

Clear                                             Clear

Carrier                                         Clear